Which of the following conditions is classified as a Lower Motor Neuron (LMN) issue?

Amyotrophic Lateral Sclerosis (ALS) is classified as a Lower Motor Neuron (LMN) issue because it primarily affects lower motor neurons that originate in the spinal cord and brainstem. In ALS, the degeneration of these neurons leads to muscle weakness, atrophy, and loss of motor function due to the disruption of the signals that would normally be sent from the lower motor neurons to the muscles.

In contrast, conditions like cerebral palsy and stroke involve the upper motor neurons, which are responsible for voluntary movement control and originate in the brain. Multiple Sclerosis (MS) also affects the central nervous system and is characterized by damage to the myelin sheath, impacting transmission of signals from the upper motor neurons.

Overall, the key distinction for ALS being a lower motor neuron condition lies in its direct impact on the neurons that connect the spinal cord to the muscles, leading to the hallmark symptoms associated with LMN disease, such as muscle weakness and atrophy.